Description

Methyl 4,4-Difluorocyclohexanecarboxylate is a high-value fluorinated building block essential for advanced organic synthesis. Its unique difluorocyclohexane core provides enhanced metabolic stability and lipophilicity, making it a critical intermediate in the development of novel active compounds. This product is primarily targeted at research and development teams in the pharmaceutical and agrochemical industries seeking to incorporate fluorine motifs into their molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the difluoro group can improve biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance display technologies.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance and material properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and ring-opening transformations to construct complex, fluorinated molecules.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D laboratories exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Product Name	Methyl 4,4-Difluorocyclohexanecarboxylate
CAS No.	882855-71-2
Molecular Formula	C8H12F2O2
Molecular Weight	178.18 g/mol
Synonyms	4,4-Difluorocyclohexanecarboxylic Acid Methyl Ester; Methyl 4,4-Difluorocyclohexanecarboxylate; 4,4-Difluorocyclohexanecarboxylic Acid, Methyl Ester; Methyl 4,4-Difluorocyclohexane-1-carboxylate; Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester; MFCD30533333; 882855-71-2
EINECS	Contact for details

Quality Control

Our Methyl 4,4-Difluorocyclohexanecarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Density (at 20°C)	~1.15 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.