Description

4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-[3-(Trifluoromethyl)Phenyl]Benzamide is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester and a benzamide scaffold. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients targeting a range of therapeutic and crop protection applications.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of new drug candidates, particularly those requiring biaryl linkages.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl halides and boronic acids/esters under mild conditions.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop molecules with improved efficacy and pharmacokinetic properties.
• Agrochemical Synthesis: Intermediate in the development of advanced herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials, such as OLEDs or conductive polymers, where specific aryl-aryl connections are needed.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development programs.

Basic Information

Product Name	4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-[3-(Trifluoromethyl)Phenyl]Benzamide
CAS No.	882678-81-1
Molecular Formula	C21H23BF3NO3
Molecular Weight	405.22 g/mol
Synonyms	N-[3-(Trifluoromethyl)phenyl]-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[3-(trifluoromethyl)phenyl]-4-methylbenzamide; 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(3-(trifluoromethyl)phenyl)benzamide; Benzamide, N-[3-(trifluoromethyl)phenyl]-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; CAS 882678-81-1
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-[3-(Trifluoromethyl)Phenyl]Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.