Description

6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazolin-2-Amine is a high-purity, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is valued for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for applications such as Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing quinazoline-based drug candidates, including kinase inhibitors and anticancer agents.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronic ester pinacol group enables efficient carbon-carbon bond formation for constructing complex biaryl structures in medicinal chemistry.
• Agrochemical Research: Used in the development of novel herbicides and fungicides that incorporate the quinazoline scaffold.
• Material Science: Serves as a precursor for organic electronic materials, such as ligands for OLEDs and other functional polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of chemical probes and affinity tags for target identification and protein profiling studies.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and library synthesis in academic and CRO laboratories.

Basic Information

Product Name	6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazolin-2-Amine
CAS No.	882670-92-0
Molecular Formula	C₁₄H₂₀BN₃O₂
Molecular Weight	273.14 g/mol
Synonyms	2-Amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline; Quinazolin-2-amine, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 6-(Pinacolboryl)quinazolin-2-amine; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-quinazolinamine; 882670-92-0; 6-(2-Aminoquinazolin-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazolin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your R&D and cGMP compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.