Description

n-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrido[2,3-D]Pyrimidin-2-Amine CAS NO 882670-91-9 is a high-purity, advanced pharmaceutical intermediate featuring a pyridopyrimidine core and a pinacol boronate ester functional group. This compound is critically important as a key building block in modern medicinal chemistry, particularly for the synthesis of targeted kinase inhibitors via Suzuki-Miyaura cross-coupling reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel anticancer and anti-inflammatory therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of small molecule kinase inhibitors for oncology and immunology research.
• Suzuki-Miyaura Cross-Coupling: The boronate ester group enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides to construct complex drug-like molecules.
• Medicinal Chemistry & Drug Discovery: Used for structure-activity relationship (SAR) studies and lead optimization in pharmaceutical R&D pipelines.
• Chemical Biology Probes: Serves as a starting material for creating tool compounds to study specific biological pathways and protein functions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university laboratories for developing new synthetic methodologies and exploring novel heterocyclic chemistry.

Basic Information

Product Name	n-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrido[2,3-D]Pyrimidin-2-Amine
CAS No.	882670-91-9
Molecular Formula	C17H23BN4O2
Molecular Weight	326.21 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methylpyrido[2,3-d]pyrimidin-2-amine; 2-Amino-N-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrido[2,3-d]pyrimidine; N-Methyl-6-(pinacolboryl)pyrido[2,3-d]pyrimidin-2-amine; 882670-91-9; Pyrido[2,3-d]pyrimidin-2-amine, N-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 6-(Pinacolboron)-N-methylpyrido[2,3-d]pyrimidin-2-amine
EINECS	Contact for details

Quality Control

Our n-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrido[2,3-D]Pyrimidin-2-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.