Description

(R)-Ethyl 3-Amino-4,4,4-Trifluorobutanoate Hcl CAS NO 882424-02-4 is a high-purity chiral building block and pharmaceutical intermediate characterized by its trifluoromethyl group and ethyl ester functionality. This compound is of significant value for its role in the synthesis of complex molecules, particularly in medicinal chemistry where the introduction of fluorine atoms can dramatically alter a compound's metabolic stability, lipophilicity, and bioavailability. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Peptidomimetics & Bioactive Molecules: Serves as a valuable precursor for constructing non-natural amino acids and peptide analogs, enabling the creation of molecules with improved pharmacological profiles.
• Ligand & Catalyst Development: Employed in asymmetric synthesis as a component for developing chiral ligands and organocatalysts, facilitating enantioselective transformations.
• Fluorine Chemistry Research: An essential compound for academic and industrial research focused on exploring the unique properties imparted by fluorine atoms in organic molecules.
• Fine Chemical Production: Utilized in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	(R)-Ethyl 3-Amino-4,4,4-Trifluorobutanoate Hydrochloride
CAS No.	882424-02-4
Molecular Formula	C6H11ClF3NO2
Molecular Weight	221.60 g/mol
Synonyms	(R)-Ethyl 3-Amino-4,4,4-trifluorobutanoate hydrochloride; Ethyl (3R)-3-amino-4,4,4-trifluorobutanoate hydrochloride; (R)-3-Amino-4,4,4-trifluorobutyric acid ethyl ester hydrochloride; (R)-Ethyl 4,4,4-trifluoro-3-aminobutanoate HCl; (R)-ATFB-OEt HCl; (R)-3-ATB ethyl ester hydrochloride; (R)-Ethyl β-amino-β-trifluoromethylpropionate hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Ethyl 3-Amino-4,4,4-Trifluorobutanoate Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity, critical for pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and titration for assay. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.