Description

5-(2-Fluorophenyl)-1-(Pyridin-3-Ylsulfonyl)-1H-Pyrrole-3-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrrole-carbaldehyde core functionalized with fluorophenyl and pyridinylsulfonyl groups. This compound is of significant value for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially those targeting central nervous system disorders and inflammatory pathways. The structural complexity of this intermediate enables precise molecular modifications critical for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, particularly for kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of new chemical entities.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard for analytical method development in pharmacokinetic studies.
• Organic Synthesis Building Block: Utilized in academic and industrial research for constructing complex heterocyclic frameworks due to its reactive aldehyde and sulfonamide functionalities.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for clinical trial material production.

Basic Information

Product Name	5-(2-Fluorophenyl)-1-(Pyridin-3-Ylsulfonyl)-1H-Pyrrole-3-Carbaldehyde
CAS No.	881677-11-8
Molecular Formula	C16H11FN2O3S
Molecular Weight	330.34 g/mol
Synonyms	1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-; 5-(2-Fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde; 1-(Pyridin-3-ylsulfonyl)-5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde; 3-Formyl-5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)pyrrole; 881677-11-8; 5-(2-Fluorophenyl)-1-(3-pyridylsulfonyl)pyrrole-3-carboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 5-(2-Fluorophenyl)-1-(Pyridin-3-Ylsulfonyl)-1H-Pyrrole-3-Carbaldehyde is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade meets a typical purity specification of ≥95% (by HPLC), suitable for research and development applications. Certificates of Analysis (COA) detailing batch-specific results for identity, assay, and impurity profiles are provided with each shipment. We support development projects with the capability to produce material under cGMP guidelines for advanced non-clinical and clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.