Description

6-(Trifluoromethyl)Pyridine-2-Boronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex molecules containing the privileged 6-(trifluoromethyl)pyridine scaffold.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethylpyridine moiety enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for functionalized ligands in catalysis and for the development of advanced organic electronic materials.
• Chemical Biology & Medicinal Chemistry: Enables the rapid generation of compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the scalable production of bespoke, boron-containing intermediates under cGMP conditions when required.

Basic Information

Product Name	6-(Trifluoromethyl)Pyridine-2-Boronic Acid Pinacol Ester
CAS No.	881402-16-0
Molecular Formula	C₁₂H₁₅BF₃NO₂
Molecular Weight	273.06 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-2-pyridineboronic acid pinacol ester; 2-(Trifluoromethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-Trifluoromethylpyridine-2-boronic acid pinacol ester; 2-Pyridineboronic acid, 6-(trifluoromethyl)-, 1,3,2-dioxaborolane, 4,4,5,5-tetramethyl- deriv.; (6-(Trifluoromethyl)pyridin-2-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 6-(Trifluoromethyl)Pyridine-2-Boronic Acid Pinacol Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling applications. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥95% by HPLC/NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain product integrity and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.