Description

(S)-1-(1,3,2-Dioxaborolan-2-Yloxy)-3-Methyl-1,1-Diphenylbutan-2-Amine is a high-purity, chiral amine-boronic ester building block of significant interest in modern synthetic chemistry. Its value lies in its dual functionality, serving as a protected amine and a boronic ester, which is crucial for constructing complex molecules with precise stereochemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for applications in asymmetric synthesis and cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, especially for central nervous system (CNS) and oncology targets.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in stereoselective transformations to introduce the (S)-configured amine center.
• Suzuki-Miyaura Cross-Coupling: The boronic ester moiety enables efficient carbon-carbon bond formation for constructing biaryl and other complex molecular architectures.
• Peptidomimetics & PROTACs Development: Serves as a versatile component in the synthesis of peptide mimics and Proteolysis Targeting Chimeras (PROTACs).
• Ligand & Catalyst Preparation: Used in the preparation of chiral ligands for asymmetric catalysis or as a precursor for metal complex catalysts.
• Academic & Process Chemistry Research: A valuable reagent for methodological studies and scaling up synthetic routes in academic and industrial R&D laboratories.

Basic Information

Item	Details
Product Name	(S)-1-(1,3,2-Dioxaborolan-2-Yloxy)-3-Methyl-1,1-Diphenylbutan-2-Amine
CAS No.	879981-94-9
Molecular Formula	C20H26BNO3
Molecular Weight	339.24 g/mol
Synonyms	(S)-3-Methyl-1,1-diphenyl-1-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)butan-2-amine; (S)-1-((4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)-3-methyl-1,1-diphenylbutan-2-amine; (S)-1,1-Diphenyl-1-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)-3-methylbutan-2-amine; Chiral Amino Boronic Ester; Pinacol Boronate Ester of a Chiral Amine
EINECS	Contact for details

Quality Control

Our (S)-1-(1,3,2-Dioxaborolan-2-Yloxy)-3-Methyl-1,1-Diphenylbutan-2-Amine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identity confirmation. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC, NMR, and chiral analysis, are validated to provide reliable specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to prevent degradation. For long-term storage, consider storing under an inert gas in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.