Description

4-Methyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine-1-Carboxamide is a high-purity, advanced pharmaceutical intermediate featuring a piperazine carboxamide core and a pinacol boronate ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex, bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key boronic ester reagent for constructing biaryl and heterobiaryl structures in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Serves as a versatile scaffold for the development of kinase inhibitors, receptor antagonists, and other small-molecule therapeutics.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize lead compounds.
• Process Chemistry & Scale-Up: Employed in the route development and kilogram-scale production of preclinical and clinical trial materials.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for target identification and validation within biological systems.
• Agrochemical Research: Potential intermediate in the discovery of new crop protection agents with novel modes of action.

Basic Information

Product Name	4-Methyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine-1-Carboxamide
CAS No.	879486-90-5
Molecular Formula	C19H30BN3O3
Molecular Weight	359.27 g/mol
Synonyms	4-Methyl-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxamide; 1-Piperazinecarboxamide, 4-methyl-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 4-Methyl-1-piperazinecarboxamide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; B-879486-90-5; 879486-90-5; 4-Methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxamide; AKOS040759656; FT-0775779
EINECS	Contact for details

Quality Control

Our 4-Methyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine-1-Carboxamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be kept sealed in a cool, dry place and allowed to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.