Description

2-(2-(Difluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a versatile and stable intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality reagents for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing difluoromethyl and biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific fluorinated aromatic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and semiconductors.
• Cross-Coupling Reactions: A dedicated reagent for palladium-catalyzed Suzuki-Miyaura couplings, facilitating carbon-carbon bond formation under mild conditions.
• Chemical Library Development: Employed in medicinal and combinatorial chemistry for the rapid generation of diverse compound libraries for screening.
• Fluorine Chemistry: The difluoromethylphenyl group makes it a valuable synthon for introducing fluorine atoms into target molecules to modulate their physicochemical properties.

Basic Information

Product Name	2-(2-(Difluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	879275-72-6
Molecular Formula	C₁₃H₁₇BF₂O₂
Molecular Weight	266.08 g/mol
Synonyms	2-(2-(Difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-(Difluoromethyl)phenyl)boronic acid pinacol ester; 2-(Difluoromethyl)phenylboronic acid pinacol ester; 1-(Difluoromethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; Pinacol [2-(difluoromethyl)phenyl]boronate; 879275-72-6; 2-(2-Difluoromethylphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of our 2-(2-(Difluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured and tested under strict quality management systems. We ensure high purity and consistency to meet the rigorous demands of research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.