Description

3,5-Dibromo-2-Methoxybenzonitrile is a versatile brominated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring strategically placed bromine atoms and a methoxy group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as Suzuki cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a building block for creating advanced organic materials, including liquid crystals and organic semiconductors (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig amination to form biaryl and other complex structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific brominated intermediates.

Basic Information

Product Name	3,5-Dibromo-2-Methoxybenzonitrile
CAS No.	879181-60-9
Molecular Formula	C8H5Br2NO
Molecular Weight	290.94 g/mol
Synonyms	2-Methoxy-3,5-dibromobenzonitrile; 3,5-Dibromo-2-methoxybenzonitrile; Benzonitrile, 3,5-dibromo-2-methoxy-; 879181-60-9
EINECS	Contact for details

Quality Control

Our 3,5-Dibromo-2-Methoxybenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.