Description

2-Fluoro-2-Methyl-Propylamine is a versatile fluorinated amine building block of significant interest in advanced organic synthesis. Its unique structure, featuring a fluorine atom adjacent to a tertiary carbon center, makes it a valuable precursor for introducing the 2-fluoro-2-methylpropyl moiety into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, as well as by fine chemical manufacturers producing specialized intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atom can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex fluorinated compounds for electronics, materials science, and specialty polymers.
• Proteolysis-Targeting Chimera (PROTAC) Linker Exploration: Investigated for use in the linker region of bifunctional PROTAC molecules due to its potential to influence pharmacokinetic properties.
• Bioconjugation Chemistry: The amine group allows for conjugation to biomolecules, peptides, or surfaces for diagnostic and research applications.

Basic Information

Product Name	2-Fluoro-2-Methyl-Propylamine
CAS No.	879121-42-3
Molecular Formula	C4H10FN
Molecular Weight	91.13 g/mol
Synonyms	2-Fluoro-2-methylpropan-1-amine; 1-Amino-2-fluoro-2-methylpropane; (2-Fluoro-2-methylpropyl)amine; 2-Fluoro-2-methyl-1-propanamine; 2-Fluoro-2-methylpropylamine; 2-Methyl-2-fluoropropylamine; α-Fluoroisobutylamine
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-2-Methyl-Propylamine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and synthesis. A detailed Certificate of Analysis (COA), including results for assay, identity, and impurity profiles (typically by GC, HPLC, and NMR), is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.