Description

4-(3-Fluorobenzyl)-1,4-Diazepan-5-One is a high-purity, advanced pharmaceutical intermediate featuring a diazepanone core with a fluorinated benzyl substituent. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted drug discovery programs. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex molecules for preclinical and clinical research.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Development: Serves in the route scouting and optimization for potential new drugs, especially those targeting neurological pathways.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Academic Research: Utilized in university and institutional labs for chemical biology and pharmacological studies.

Basic Information

Product Name	4-(3-Fluorobenzyl)-1,4-Diazepan-5-One
CAS No.	879050-48-3
Molecular Formula	C12H15FN2O
Molecular Weight	222.26 g/mol
Synonyms	1,4-Diazepan-5-one, 4-[(3-fluorophenyl)methyl]-; 4-(3-Fluorobenzyl)-1,4-diazepan-5-one; 4-(3-Fluorobenzyl)-1,4-diazepan-5-one; 4-(3-Fluorobenzyl)-1,4-diazepan-5-one; 879050-48-3; 4-(3-Fluorobenzyl)-1,4-diazepan-5-one; 4-(3-Fluorobenzyl)-1,4-diazepan-5-one
EINECS	Contact for details

Quality Control

Our 4-(3-Fluorobenzyl)-1,4-Diazepan-5-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and stored away from direct light and moisture sources.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.