Description

2,2,2-Trifluoro-1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Dihydropyridin-1(2H)-Yl)Ethanone is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds in medicinal chemistry. It is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing complex drug candidates, particularly those requiring fluorinated or heterocyclic motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a boronic ester coupling partner to introduce the dihydropyridine moiety into target molecules under mild conditions.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Precursor: Serves as a starting material for creating organic electronic materials and liquid crystals.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds for target identification and binding studies.
• Academic & Contract Research: Essential reagent for methodology development and complex molecule synthesis in research laboratories.

Basic Information

Product Name	2,2,2-Trifluoro-1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Dihydropyridin-1(2H)-Yl)Ethanone
CAS No.	878805-74-4
Molecular Formula	C15H21BF3NO3
Molecular Weight	331.14 g/mol
Synonyms	1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridin-1-yl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridin-1-yl]ethanone; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2H)-yl)-2,2,2-trifluoroethanone; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroacetyl)-1,2,3,6-tetrahydropyridine; Trifluoroacetyl-protected Dihydropyridine Boronic Ester Pinacol Ester.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR (1H, 13C, 19F, 11B), and GC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity (typically >95% by HPLC), assay, and impurity profile is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. The compound is moisture-sensitive and should be handled in a dry environment. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (NMR)	≥ 97%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.