Description

(S)-2-Amino-3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Propionic Acid CAS NO 878384-69-1 is a high-purity, non-natural amino acid derivative featuring a key boronic ester functional group. This compound is a critical building block in modern pharmaceutical research, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily utilized by pharmaceutical R&D and biotech organizations for the development of targeted therapeutics and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for protease inhibitors and enzyme-targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronate ester reagent for constructing biaryl and other complex carbon-carbon bonds under mild conditions.
• Peptidomimetics & Protein Engineering: Used to incorporate boron-containing moieties into peptide backbones to modulate biological activity, stability, and binding affinity.
• Boron Neutron Capture Therapy (BNCT) Research: Investigated as a potential precursor for developing tumor-targeting agents due to the boron-10 isotope's therapeutic properties.
• Chemical Biology Probes: Enables the creation of activity-based probes and affinity labels for studying enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Provides a chiral center for the stereoselective construction of complex organic molecules in medicinal chemistry.

Basic Information

Product Name	(S)-2-Amino-3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Propionic Acid
CAS No.	878384-69-1
Molecular Formula	C15H22BNO4
Molecular Weight	291.15 g/mol
Synonyms	L-Boronophenylalanine Pinacol Ester; (S)-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenylalanine; BOC-L-4-Boronophenylalanine Pinacol Ester; 4-Boronophenylalanine Pinacol Ester; BPA Pinacol Ester; L-4-Boronophenylalanine Pinacol Ester; BOC-Bpa(Pin)-OH; (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic Acid
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Propionic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric excess, meeting the stringent requirements for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.