Description

2-Chloro-3-Cyanopyridin-4-Ylboronic Acid CAS NO 878194-88-8 is a high-value boronic acid derivative and a versatile building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex heterocyclic systems through reliable cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron-containing partner for constructing biaryl and heterobiaryl structures central to many drug candidates.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides with pyridine-based scaffolds.
• Material Science: Employed in the creation of organic electronic materials, ligands for catalysis, and functionalized polymers.
• Chemical Biology & Proteomics: Utilized as a tool compound or building block for creating molecular probes and bioconjugates.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	2-Chloro-3-Cyanopyridin-4-Ylboronic Acid
CAS No.	878194-88-8
Molecular Formula	C6H4BClN2O2
Molecular Weight	182.37 g/mol
Synonyms	(2-Chloro-3-cyano-4-pyridinyl)boronic acid; 2-Chloro-3-cyano-4-pyridineboronic acid; 4-Borono-2-chloro-3-cyanopyridine; 2-Chloro-3-cyanopyridine-4-boronic acid; 2-Chloro-3-cyanopyridin-4-ylboronic acid pinacol ester (protected form); B-(2-Chloro-3-cyano-4-pyridinyl)boronic acid; 878194-88-8 (CAS).
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Cyanopyridin-4-Ylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.