Description

tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine core and a versatile boronic ester pinacol group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex bioactive molecules. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Medicinal Chemistry R&D: Used extensively in lead optimization and library synthesis for creating novel compounds targeting various disease pathways.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, and insecticides with improved efficacy.
• Ligand and Catalyst Development: Employed in the research and preparation of novel ligands and organometallic catalysts.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological processes and target identification.
• Material Science Research: A potential monomer or precursor for advanced polymers and functional organic materials.

Basic Information

Item	Details
Product Name	tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Piperidine-1-Carboxylate
CAS No.	877399-74-1
Molecular Formula	C19H34BN3O4
Molecular Weight	379.30 g/mol
Synonyms	1-Boc-4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine; tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate; 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-4-(4-(pinacolboranyl)-1H-pyrazol-1-yl)piperidine; BOC-Piperidine-Pyrazole-Boronic Ester Pinacol; 877399-74-1
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Piperidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.