Description

Oxazole, 2,2'-(1,3-Phenylene)Bis[4,5-Dihydro-4-Phenyl-, (4S,4'S)- is a high-purity, chiral bis-oxazoline derivative of significant interest in advanced chemical synthesis. This compound matters as a sophisticated ligand precursor or catalyst for asymmetric transformations, enabling the production of enantiomerically pure intermediates. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors who require precise stereochemical control in their synthetic processes.

Application

• Asymmetric Catalysis: Serving as a precursor for chiral bis-oxazoline ligands used in enantioselective C-H activation, cyclopropanation, Diels-Alder, and aldol reactions.
• Pharmaceutical Intermediate Synthesis: Enabling the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, infectious diseases, and metabolic conditions.
• Agrochemical Research: Facilitating the development of chiral herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Material Science: Potential use in the synthesis of chiral polymers or metal-organic frameworks (MOFs) with specialized optical or catalytic properties.
• Academic & Process Chemistry: A valuable tool for methodological development in organic synthesis and scale-up studies for industrial processes.

Basic Information

Product Name	Oxazole, 2,2'-(1,3-Phenylene)Bis[4,5-Dihydro-4-Phenyl-, (4S,4'S)-
CAS No.	876953-19-4
Molecular Formula	C30H26N2O2
Molecular Weight	446.54 g/mol
Synonyms	(4S,4'S)-2,2'-(1,3-Phenylene)bis(4,5-dihydro-4-phenyloxazole); (S,S)-1,3-Phenylenebis(4,5-dihydro-4-phenyl-2-oxazole); (S,S)-2,2'-(1,3-Phenylene)bis(4,5-dihydro-4-phenyloxazole); Chiral 1,3-Bis(oxazolinyl)benzene Derivative; (S,S)-PHANOL; (S,S)-1,3-Bis(4,5-dihydro-4-phenyl-2-oxazolyl)benzene; Ligand Precursor 876953-19-4; (S,S)-m-Phenylenebis(4-phenyl-4,5-dihydrooxazole)
EINECS	Contact for details

Quality Control

Our Oxazole, 2,2'-(1,3-Phenylene)Bis[4,5-Dihydro-4-Phenyl-, (4S,4'S)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and specific rotation measurement. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.