Description

1-Bromo-4,5-Difluoro-2-Methyl-Benzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for selective functionalization and incorporation into complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorinated aromatic motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the bromine atom serves as a versatile handle for further cross-coupling reactions.
• Liquid Crystal & OLED Material Precursor: Serves as a foundational building block for the development of fluorinated organic electronic materials and liquid crystal compounds.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Organic Synthesis Research: Employed in academic and industrial R&D for method development and the exploration of new chemical spaces in medicinal and materials chemistry.
• Fluorine Chemistry Studies: Used as a model compound to study the electronic effects and reactivity of adjacent fluorine and bromine substituents on an aromatic ring.

Basic Information

Product Name	1-Bromo-4,5-Difluoro-2-Methyl-Benzene
CAS No.	875664-38-3
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	4,5-Difluoro-2-methylbromobenzene; 2-Bromo-4,5-difluorotoluene; 1-Bromo-4,5-difluoro-2-methylbenzene; 4,5-Difluoro-2-methyl-1-bromobenzene; 2-Methyl-4,5-difluorobromobenzene; Toluene, 2-bromo-4,5-difluoro-; Bromo-difluorotoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4,5-Difluoro-2-Methyl-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the consistency and reliability required for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Purity (HPLC/GC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.