Description

1H-Pyrrolo[2,3-B]Pyridine, 3-(3-Furanyl)-1-[(4-Methylphenyl)Sulfonyl]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional heterocyclic compound that serves as a critical advanced pharmaceutical intermediate and Suzuki-Miyaura cross-coupling reagent. Its unique structure, featuring a protected boronic ester group, makes it indispensable for constructing complex molecular architectures in medicinal chemistry. This product is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other small-molecule therapeutics targeting oncology and CNS diseases.
• Suzuki-Miyaura Cross-Coupling: The boronic ester moiety enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, crucial for constructing biaryl systems in drug discovery.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study biological pathways and protein functions.
• Agrochemical Synthesis: Intermediate for developing novel, high-performance crop protection agents with complex heterocyclic cores.
• Material Science Research: Potential precursor for organic electronic materials and ligands in catalytic systems.

Basic Information

Item	Details
Product Name	1H-Pyrrolo[2,3-B]Pyridine, 3-(3-Furanyl)-1-[(4-Methylphenyl)Sulfonyl]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	875639-27-3
Molecular Formula	C24H25BN2O5S
Molecular Weight	464.34 g/mol
Synonyms	3-(Furan-3-yl)-1-(4-methylphenyl)sulfonyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1-Tosyl-3-(3-furyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-Boronic acid, 3-(3-furanyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; 875639-27-3; BRN 16219362
EINECS	Contact for details

Quality Control

Our high-purity advanced intermediates are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation, to ensure consistency and reliability for sensitive R&D and scale-up processes. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.