Description

1H-Pyrrolo[2,3-B]Pyridine, 1-[(4-Methylphenyl)Sulfonyl]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(2-Thiazolyl)- is a sophisticated, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound matters because it combines a protected boronic ester functionality with a complex pyrrolopyridine-thiazole core, making it an invaluable intermediate for constructing novel molecular architectures. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery, catalyst development, and material science.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas, including kinase inhibitors and antiviral agents.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group enables efficient palladium-catalyzed cross-coupling to introduce the complex heterocyclic moiety into target molecules.
• Medicinal Chemistry & Lead Optimization: Used for the rapid exploration of structure-activity relationships (SAR) by facilitating the late-stage functionalization of drug candidates.
• Agrochemical Research: Serves as a precursor in the development of novel pesticides and herbicides with enhanced efficacy.
• Material Science & Organic Electronics: Potential use in the synthesis of organic semiconductors and light-emitting materials due to its extended π-conjugated system.
• Chemical Biology Probes: Useful for creating tagged molecules to study biological pathways and protein interactions.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 1-[(4-Methylphenyl)Sulfonyl]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(2-Thiazolyl)-
CAS No.	875639-26-2
Molecular Formula	C23H24BN3O4S2
Molecular Weight	481.39 g/mol
Synonyms	1-Tosyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(thiazol-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1-[(4-Methylphenyl)sulfonyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(1,3-thiazol-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2-thiazolyl)-; 875639-26-2; Boronic acid, B-[1-[(4-methylphenyl)sulfonyl]-3-(2-thiazolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our high-value chemical intermediates are produced under strict quality management systems to ensure batch-to-batch consistency and purity. Each lot undergoes comprehensive analytical characterization, including NMR (1H, 13C, 11B), HPLC, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for advanced intermediates intended for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.