Description

1H-Pyrrolo[2,3-B]Pyridine, 3-(2,3-Dihydro-7-Benzofuranyl)-1-[(4-Methylphenyl)Sulfonyl]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a unique fused heterocyclic structure with a key boronic ester pinacol group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl systems. It is an essential building block for research and development chemists in the pharmaceutical and agrochemical industries, targeting the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and antiviral research.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronic ester functionality enables efficient carbon-carbon bond formation to create complex, drug-like molecules.
• Agrochemical Research: Used in the development of new pesticides and herbicides with enhanced efficacy and selectivity.
• Material Science: Serves as a building block for organic electronic materials, such as OLEDs and semiconductors, due to its conjugated system.
• Academic & Contract Research: A valuable tool for synthetic methodology development and exploration of new chemical space in university and CRO laboratories.
• Library Synthesis: Ideal for generating diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 3-(2,3-Dihydro-7-Benzofuranyl)-1-[(4-Methylphenyl)Sulfonyl]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	875639-25-1
Molecular Formula	C28H29BN2O5S
Molecular Weight	516.42 g/mol
Synonyms	3-(2,3-Dihydrobenzofuran-7-yl)-1-(4-methylphenyl)sulfonyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1-Tosyl-3-(2,3-dihydrobenzofuran-7-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-Boronic acid pinacol ester of 1H-Pyrrolo[2,3-B]Pyridine derivative; Borylation product of 1H-Pyrrolo[2,3-B]Pyridine; Suzuki Coupling Boronate Ester Intermediate; CAS 875639-25-1
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management protocols. We employ state-of-the-art analytical techniques including HPLC, NMR, and LC-MS to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and quality documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.