Description

(2R)-2-(Fluoromethyl)-Pyrrolidine CAS NO 875608-74-5 is a high-purity, chiral fluorinated pyrrolidine building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) where its fluorine atom and stereochemistry can dramatically influence biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated active ingredients for crop protection products, leveraging fluorine's ability to enhance bioavailability and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization to introduce fluoromethyl groups into target molecules.
• Process Chemistry & Scale-up: Used in route scouting and optimization for the commercial-scale manufacturing of fluorinated APIs.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring new methodologies for incorporating fluorine into heterocyclic systems.

Basic Information

Item	Details
Product Name	(2R)-2-(Fluoromethyl)-Pyrrolidine
CAS No.	875608-74-5
Molecular Formula	C5H10FN
Molecular Weight	103.14 g/mol
Synonyms	(R)-2-(Fluoromethyl)pyrrolidine; (2R)-2-Fluoromethylpyrrolidine; (R)-(-)-2-(Fluoromethyl)pyrrolidine; (R)-2-Fluoromethyl-pyrrolidine; Pyrrolidine, 2-(fluoromethyl)-, (2R)-; 875608-74-5; (R)-2-(Fluoromethyl)azacyclopentane
EINECS	Contact for details

Quality Control

Our (2R)-2-(Fluoromethyl)-Pyrrolidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, chemical assay, and impurity profiles. Our quality management system is designed to meet the rigorous demands of our global customer base in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.