Description

Ethyl trans-1-Benzyl-4-(4-Fluorophenyl)Pyrrolidine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly those targeting the central nervous system. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its pyrrolidine scaffold and fluorophenyl moiety.
• Process Development: Serves as a critical intermediate in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under GMP conditions.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Chemical Biology Probes: Utilized in the development of tool compounds for investigating biological pathways and target engagement.

Basic Information

Product Name	Ethyl trans-1-Benzyl-4-(4-Fluorophenyl)Pyrrolidine-3-Carboxylate
CAS No.	874990-58-6
Molecular Formula	C20H22FNO2
Molecular Weight	327.40 g/mol
Synonyms	trans-Ethyl 1-benzyl-4-(4-fluorophenyl)pyrrolidine-3-carboxylate; 1-Benzyl-4-(4-fluorophenyl)-3-pyrrolidinecarboxylic Acid Ethyl Ester (trans); Ethyl (3R,4S)-1-Benzyl-4-(4-fluorophenyl)pyrrolidine-3-carboxylate; Ethyl (3S,4R)-1-Benzyl-4-(4-fluorophenyl)pyrrolidine-3-carboxylate; 874990-58-6; 1-Benzyl-4-(p-fluorophenyl)pyrrolidine-3-carboxylic Acid Ethyl Ester; trans-1-Benzyl-4-(4-fluorophenyl)-3-(ethoxycarbonyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our Ethyl trans-1-Benzyl-4-(4-Fluorophenyl)Pyrrolidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.