Description

4,4,5,5-Tetramethyl-2-(5-Methylthiophen-3-Yl)-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a pinacol boronic ester derivative. This compound is essential for modern synthetic chemistry, enabling precise carbon-carbon bond formation through cross-coupling reactions. It is primarily utilized by pharmaceutical, agrochemical, and advanced materials researchers for the efficient synthesis of complex molecules and functional materials. Its stability and reactivity profile make it a critical reagent for medicinal chemistry and process development.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl structures prevalent in active pharmaceutical ingredients (APIs) and organic electronic materials.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, particularly those containing functionalized thiophene moieties.
• Agrochemical Development: Serves as a building block for creating new herbicides, fungicides, and insecticides with tailored properties.
• Material Science & Organic Electronics: Employed in the synthesis of monomers and precursors for conductive polymers, organic light-emitting diodes (OLEDs), and semiconductors.
• Chemical Biology & Probe Development: Useful for labeling and modifying biomolecules or creating molecular probes for diagnostic applications.
• Process Chemistry & Scale-Up: Provides a reliable and scalable route for the industrial production of fine chemicals and advanced intermediates.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(5-Methylthiophen-3-Yl)-1,3,2-Dioxaborolane
CAS No.	874959-74-7
Molecular Formula	C13H21BO2S
Molecular Weight	252.18 g/mol
Synonyms	5-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene; 2-(5-Methylthiophen-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (5-Methylthiophen-3-yl)boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methylthiophene; 5-Methyl-3-thienylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-(5-Methylthiophen-3-Yl)-1,3,2-Dioxaborolane adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.