Description

2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its core value proposition lies in enabling precise carbon-carbon bond formation, which is essential for constructing complex molecular architectures in advanced research and development. This compound is primarily needed by pharmaceutical R&D teams, agrochemical scientists, and specialty chemical manufacturers for applications in medicinal chemistry, material science, and catalysis.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides by facilitating the introduction of the benzonitrile moiety into complex molecules.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials, due to its electron-withdrawing nitrile group and boronate functionality.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organoboron catalysts used in asymmetric synthesis and polymerization processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	874472-84-1
Molecular Formula	C14H18BNO3
Molecular Weight	259.11 g/mol
Synonyms	3-Cyano-2-methoxyphenylboronic acid pinacol ester; 2-Methoxy-3-cyanophenylboronic acid pinacol ester; (3-Cyano-2-methoxyphenyl)boronic acid pinacol ester; 2-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 874472-84-1; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxybenzonitrile; Boronic acid, B-(3-cyano-2-methoxyphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of 2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including NMR (1H, 13C, 11B), HPLC, and GC, to ensure high purity and consistency for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.