Description

Boronic Acid, [2-(1-Pyrrolidinylcarbonyl)Phenyl]- is a specialized organoboron compound featuring a phenylboronic acid core linked to a pyrrolidine amide moiety. This structure makes it a valuable high-purity building block for medicinal chemistry and pharmaceutical research, particularly in the development of protease inhibitors and other bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable synthetic intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially those targeting proteases like thrombin or factor Xa.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and for creating focused libraries for high-throughput screening.
• Suzuki-Miyaura Cross-Coupling: Serves as an organoboron reagent for forming carbon-carbon bonds to construct complex biaryl structures common in active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Employed in the development of molecular probes that leverage boronic acid's affinity for diols, useful for sensing or targeting applications.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents with specific modes of action.
• Advanced Material Development: Building block for creating novel polymers or organic electronic materials with tailored properties.

Basic Information

Product Name	Boronic Acid, [2-(1-Pyrrolidinylcarbonyl)Phenyl]-
CAS No.	874459-80-0
Molecular Formula	C11H14BNO3
Molecular Weight	219.05 g/mol
Synonyms	2-(1-Pyrrolidinecarbonyl)phenylboronic acid; 2-(Pyrrolidine-1-carbonyl)phenylboronic acid; [2-(Pyrrolidine-1-carbonyl)phenyl]boronic acid; 2-Carbamoylphenylboronic acid, N-pyrrolidine derivative; B-[2-(1-Pyrrolidinylcarbonyl)phenyl]boronic acid; Amide-linked pyrrolidine phenylboronic acid; (2-(Pyrrolidine-1-carbonyl)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Our Boronic Acid, [2-(1-Pyrrolidinylcarbonyl)Phenyl]- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤1.0%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.