Description

1-(3-Fluorophenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea is a high-purity, functionalized urea derivative containing a boronic ester protecting group. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry research, particularly in the development of kinase inhibitors and targeted therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for advanced synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of biologically active molecules, especially kinase inhibitors and other small-molecule drug candidates.
• Suzuki-Miyaura Cross-Coupling Reactions: The tetramethyl-1,3,2-dioxaborolan-2-yl (pinacol boronate ester) group makes it a valuable reagent for palladium-catalyzed cross-coupling to form biaryl structures, a fundamental transformation in modern organic synthesis.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile building block for constructing compound libraries and exploring structure-activity relationships (SAR) in lead optimization.
• Chemical Biology Probes: Used in the development of chemical probes to study enzyme function and biological pathways.
• Advanced Material Synthesis: Potential use as a monomer or functional unit in the synthesis of specialty polymers and organic electronic materials.

Basic Information

Product Name	1-(3-Fluorophenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea
CAS No.	874302-03-1
Molecular Formula	C19H22BFN2O3
Molecular Weight	356.20 g/mol
Synonyms	3-(3-(3-Fluorophenyl)ureido)phenylboronic acid pinacol ester; 1-(3-Fluorophenyl)-3-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; N-(3-Fluorophenyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; Urea, N-(3-fluorophenyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 874302-03-1; B-[3-[[(3-Fluorophenyl)amino]carbonyl]amino]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(3-Fluorophenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and to support regulatory filings. We can supply material compliant with ICH guidelines for impurities in pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.