Description

1-(4-Fluorophenyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is a high-value pharmaceutical intermediate and chemical building block featuring a urea linkage and a boronic ester pinacol group. This compound matters for its critical role in modern synthetic chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting CNS disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronic ester moiety facilitates palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Agrochemical Research: Used in the development of new herbicides and fungicides with enhanced efficacy.
• Material Science: Serves as a precursor for creating functional polymers and organic electronic materials.
• Chemical Biology & Proteomics: Can be utilized in the design of enzyme inhibitors and activity-based probes.
• Academic & Contract Research: Essential for methodological development and discovery chemistry in laboratory settings.

Basic Information

Product Name	1-(4-Fluorophenyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea
CAS No.	874301-65-2
Molecular Formula	C19H22BFN2O3
Molecular Weight	356.20 g/mol
Synonyms	N-(4-Fluorophenyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 1-(4-Fluorophenyl)-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 3-(4-Fluorophenyl)-1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; Urea, N-(4-fluorophenyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 874301-65-2; Boric acid, [3-[[[(4-fluorophenyl)amino]carbonyl]amino]phenyl]-, 2,2-dimethyltrimethylene ester
EINECS	Contact for details

Quality Control

Our 1-(4-Fluorophenyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.