Description

1-(4-Methoxyphenyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is a high-value boronic ester-protected urea derivative, a critical intermediate in modern synthetic chemistry. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing new active ingredients, as well as in advanced materials science for creating novel organic electronic components.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly those containing biphenyl or phenyl-heteroaryl motifs prevalent in kinase inhibitors and GPCR modulators.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages for optimal activity.
• Material Science Research: Serves as a precursor for constructing conjugated organic molecules used in OLEDs, OFETs, and other organic electronic devices.
• Chemical Biology & Proteomics: Can be utilized in the development of activity-based probes or affinity reagents that target specific enzymes or proteins.
• Academic & R&D Laboratories: A versatile reagent for methodological development in cross-coupling chemistry and for synthesizing complex molecular libraries for screening.

Basic Information

Product Name	1-(4-Methoxyphenyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea
CAS No.	874301-63-0
Molecular Formula	C20H25BN2O4
Molecular Weight	368.24 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-methoxyphenyl)benzamide; 1-(4-Methoxyphenyl)-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; Urea, N-(4-methoxyphenyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl 4-methoxyphenylurea; Boronic ester urea derivative
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Methoxyphenyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. A detailed Certificate of Analysis (COA) specifying identity, purity (typically ≥95% by HPLC), and impurity profile is supplied with each shipment to guarantee reproducible performance and supply chain reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.