Description

1-(Furan-2-Ylmethyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is a sophisticated boronic ester-protected urea derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in the combination of a protected boronic acid handle and a urea pharmacophore, enabling precise molecular construction for advanced material and pharmaceutical research. This compound is essential for medicinal chemists and process development scientists engaged in Suzuki-Miyaura cross-coupling reactions and the development of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition or requiring specific urea-based scaffolds.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group acts as a stable, reactive handle for palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Chemical Biology Probe Development: Used to create tagged or modified molecules for studying protein-ligand interactions and cellular pathways.
• Material Science Research: Serves as a monomer or functionalization agent in the development of novel polymers and organic electronic materials.
• Agrochemical Synthesis: Intermediate in the research and development of new herbicides or fungicides with targeted activity.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological activity screening in drug discovery.

Basic Information

Product Name	1-(Furan-2-Ylmethyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea
CAS No.	874299-16-8
Molecular Formula	C19H25BN2O4
Molecular Weight	356.23 g/mol
Synonyms	1-(Furan-2-ylmethyl)-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 3-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-(furfuryl)urea; 1-(Furfuryl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea; Urea, N-(2-furanylmethyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; Boronophenyl Urea Furan Derivative; CAS 874299-16-8; Pinacol [3-({[(furan-2-yl)methyl]carbamoyl}amino)phenyl]boronate
EINECS	Contact for details

Quality Control

Every batch of 1-(Furan-2-Ylmethyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure high purity and batch-to-batch consistency suitable for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.