Description

1-Cyclopentyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is a high-value, advanced pharmaceutical intermediate featuring a urea linkage and a protected boronic acid pinacol ester functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing biaryl scaffolds. It is an essential building block for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who are developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those containing complex biaryl structures for oncology, CNS, and metabolic disease targets.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester moiety serves as a stable, reactive handle for palladium-catalyzed carbon-carbon bond formation with aryl halides or triflates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to rapidly generate diverse compound libraries.
• Agrochemical Synthesis: Employed in the development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science: Potential building block for creating organic electronic materials, such as those used in OLEDs or organic photovoltaics, where conjugated systems are critical.
• Chemical Biology Probes: Can be utilized to synthesize molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	1-Cyclopentyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea
CAS No.	874299-11-3
Molecular Formula	C18H27BN2O3
Molecular Weight	330.23 g/mol
Synonyms	3-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-cyclopentylurea; 1-Cyclopentyl-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; N-Cyclopentyl-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; Urea, N-cyclopentyl-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; CAS 874299-11-3
EINECS	Contact for details

Quality Control

Our 1-Cyclopentyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive coupling reactions. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality protocols are designed to meet the stringent requirements of cGMP and ICH guidelines for pharmaceutical intermediates. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.