Description

1-(tert-Butyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is a high-value, functionalized boronic ester derivative that serves as a critical synthetic intermediate. Its molecular architecture, featuring a protected boronate group and a urea linkage, makes it an essential building block for constructing complex molecules in advanced research and development. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for applications in medicinal chemistry, particularly in the synthesis of kinase inhibitors and other bioactive small molecules. Its reliable quality and consistent performance are vital for accelerating drug discovery pipelines and material science projects.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted therapeutics, especially for kinase inhibitor libraries and protease inhibitors.
• Medicinal Chemistry Research: Used in Suzuki-Miyaura cross-coupling reactions to introduce aryl groups into complex molecular scaffolds during hit-to-lead and lead optimization stages.
• Agrochemical Development: Intermediate in the research and synthesis of novel active ingredients with specific biological activity.
• Material Science: Potential monomer or precursor for constructing organic electronic materials, polymers, or metal-organic frameworks (MOFs).
• Chemical Biology: Utilized in the development of chemical probes and tools for studying biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and advanced intermediates.

Basic Information

Product Name	1-(tert-Butyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea
CAS No.	874299-09-9
Molecular Formula	C₁₇H₂₇BN₂O₃
Molecular Weight	318.22 g/mol
Synonyms	1-tert-Butyl-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 3-(1,1-Dimethylethyl)-1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 1-(tert-Butyl)-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; N-(tert-Butyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; Urea, N-(1,1-dimethylethyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 874299-09-9; Boric acid, [3-[[[(1,1-dimethylethyl)amino]carbonyl]amino]phenyl]-, 2,2-dimethyltrimethylene ester
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Quality Control

Our 1-(tert-Butyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Production adheres to cGMP guidelines where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by techniques including HPLC, NMR, and mass spectrometry. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.