Description

1-Butyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is a high-purity, advanced pharmaceutical intermediate and research chemical featuring a boronic ester-protected phenylurea scaffold. This compound is critical for modern synthetic chemistry, particularly in the development of targeted therapeutics and novel materials via cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, proteolysis-targeting chimera (PROTAC) development, and the synthesis of kinase inhibitors.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted small-molecule drugs.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop novel therapeutic candidates.
• PROTAC (Proteolysis-Targeting Chimera) Development: Serves as a versatile linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester group enables efficient carbon-carbon bond formation, essential for constructing complex organic molecules.
• Chemical Biology Research: Employed as a probe or tool compound for studying enzyme function and biological pathways.
• Material Science: Potential precursor for creating functional organic polymers or boron-containing advanced materials.

Basic Information

Product Name	1-Butyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea
CAS No.	874299-07-7
Molecular Formula	C₁₇H₂₇BN₂O₃
Molecular Weight	318.22 g/mol
Synonyms	1-Butyl-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-butylphenylurea; N-Butyl-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; Urea, N-butyl-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; B-[3-[(Butylamino)carbonyl]amino]phenyl]boronic acid, pinacol ester; CAS 874299-07-7
EINECS	Contact for details

Quality Control

Our 1-Butyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.