Description

1-Isopropyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is a high-purity, advanced pharmaceutical intermediate and building block of significant importance in modern synthetic chemistry. Its core value lies in its unique molecular structure, which incorporates a protected boronic ester group, making it a critical reagent for Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly for targeted therapies and complex molecule synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted small-molecule drugs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds, a fundamental step in constructing complex aromatic and heteroaromatic systems.
• Agrochemical Research & Development: Used in the discovery and synthesis of novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science & OLED Development: Employed in the creation of novel organic electronic materials, including ligands for catalysts and components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Synthesis: Utilized for labeling and modifying biomolecules or for creating chemical probes to study biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	1-Isopropyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea
CAS No.	874299-06-6
Molecular Formula	C16H25BN2O3
Molecular Weight	304.20 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(propan-2-yl)phenylurea; 1-Isopropyl-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; Urea, N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-(1-methylethyl)-; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl Isopropyl Urea; (3-((Isopropylcarbamoyl)amino)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Isopropyl-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliable batch-to-batch consistency for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.