Description

n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxamide is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those requiring complex aryl-aryl bond formations.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a stable, air-tolerant boronic ester partner for palladium-catalyzed coupling with aryl halides or triflates.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• Chemical Biology Probes: Employed in the development of molecular probes and tools for studying biological pathways and target engagement.
• Agrochemical Synthesis: Intermediate in the research and development of new crop protection agents with complex aromatic backbones.
• Material Science Precursor: Potential monomer or building block for advanced organic electronic materials and polymers.

Basic Information

Product Name	n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxamide
CAS No.	874299-01-1
Molecular Formula	C18H27BN2O3
Molecular Weight	330.23 g/mol
Synonyms	3-(1-Carbamoylpiperidin-4-yl)phenylboronic acid pinacol ester; 1-Piperidinecarboxamide, N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 3-(Piperidine-1-carboxamido)phenylboronic acid pinacol ester; 874299-01-1; N-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxamide; B-[3-(1-Piperidinecarboxamido)phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.