Description

n-[(4-Chlorophenyl)Methyl]-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea is a high-value, functionalized urea derivative containing a pinacol boronate ester group, making it a critical advanced pharmaceutical intermediate and Suzuki-Miyaura cross-coupling precursor. This compound is specifically engineered for the synthesis of complex molecules where precise carbon-boron bond formation is required. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) for oncology, CNS, and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds in complex molecule assembly.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new drug candidates.
• Ligand and Catalyst Development: Precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science: Intermediate in the synthesis of organic electronic materials and polymers with tailored properties.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and plant growth regulators.

Basic Information

Product Name	n-[(4-Chlorophenyl)Methyl]-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea
CAS No.	874298-88-1
Molecular Formula	C20H24BClN2O3
Molecular Weight	386.68 g/mol
Synonyms	1-[(4-Chlorophenyl)methyl]-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; N-(4-Chlorobenzyl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; Urea, N-[(4-chlorophenyl)methyl]-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 4-(N'-(4-Chlorobenzyl)ureido)phenylboronic acid pinacol ester; (4-((((4-Chlorobenzyl)carbamoyl)amino)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of n-[(4-Chlorophenyl)Methyl]-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea adheres to stringent GMP-like guidelines to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality systems are designed to meet the exacting standards of global pharmaceutical and R&D customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original sealed packaging to prevent degradation. For long-term storage, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.