Description

Urea, n-[(4-Fluorophenyl)Methyl]-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- is a high-value, functionalized urea derivative containing a pinacol boronate ester group, making it a crucial synthetic intermediate. This compound is specifically engineered for applications in modern pharmaceutical discovery and advanced materials science, where precise molecular construction is paramount. It is primarily sought after by research institutions and industrial R&D departments focused on developing novel therapeutics, agrochemicals, and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting kinase inhibition and other protein-protein interactions.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety enables efficient palladium-catalyzed cross-coupling for biaryl bond formation, a fundamental reaction in medicinal chemistry.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component connecting E3 ligase ligands to target protein binders, facilitating targeted protein degradation.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and plant growth regulators with enhanced selectivity and efficacy.
• Materials Science: Used in the synthesis of organic electronic materials, such as novel polymers or small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Enables the creation of molecular probes for studying biological pathways and enzyme functions.

Basic Information

Product Name	Urea, n-[(4-Fluorophenyl)Methyl]-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-
CAS No.	874298-25-6
Molecular Formula	C20H24BFN2O3
Molecular Weight	370.23 g/mol
Synonyms	1-[(4-Fluorobenzyl)]-3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; N-[(4-Fluorophenyl)methyl]-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 4,4,5,5-Tetramethyl-2-[4-[[[[(4-fluorophenyl)methyl]amino]carbonyl]amino]phenyl]-1,3,2-dioxaborolane; (4-((((4-Fluorobenzyl)carbamoyl)amino)phenyl)boronic acid pinacol ester; 4-Fluorobenzyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea
EINECS	Contact for details

Quality Control

Our production of Urea, n-[(4-Fluorophenyl)Methyl]-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry for comprehensive characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.