Description

1-(4-Methoxybenzyl)-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is a high-purity boronic ester-protected urea derivative, serving as a critical synthetic intermediate in modern organic and medicinal chemistry. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing novel active pharmaceutical ingredients (APIs) and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in creating advanced herbicides, fungicides, and insecticides with specific modes of action.
• Material Science: Precursor for organic electronic materials, such as OLEDs and organic semiconductors, via polymerization or functionalization.
• Chemical Biology: Probe or linker molecule in bioconjugation and proteomics research due to its reactive boronate and urea groups.
• Academic & R&D: Versatile reagent for methodological development in cross-coupling chemistry and heterocycle synthesis.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for clients.

Basic Information

Product Name	1-(4-Methoxybenzyl)-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea
CAS No.	874298-21-2
Molecular Formula	C21H27BN2O4
Molecular Weight	382.26 g/mol
Synonyms	N-(4-Methoxybenzyl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 1-(4-Methoxybenzyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl 1-(4-Methoxybenzyl)urea; Urea, N-(4-methoxybenzyl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; B-[4-[[[(4-Methoxyphenyl)methyl]amino]carbonyl]amino]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(4-Methoxybenzyl)-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.