Description

4-Methyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxamide is a high-value pharmaceutical intermediate and building block featuring a protected boronic acid ester (pinacol boronate) group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly those requiring a piperidine-carboxamide scaffold linked to an aryl boronate.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between its aryl boronate group and various organic halides, essential for creating diverse chemical libraries.
• Agrochemical Research: Used in the discovery and development of new active ingredients for crop protection products.
• Material Science: Serves as a monomer or precursor in the development of advanced organic electronic materials and polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed as a linker or functional component in the design of bifunctional molecules for targeted protein degradation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development programs.

Basic Information

Product Name	4-Methyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxamide
CAS No.	874297-89-9
Molecular Formula	C20H31BN2O3
Molecular Weight	358.29 g/mol
Synonyms	4-Methyl-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine-1-carboxamide; 1-[(4-Methylpiperidin-1-yl)carbonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-methylpiperidin-1-yl)benzamide; 874297-89-9; Aryl Pinacol Boronate Ester Intermediate
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxamide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.