Description

1-Methoxy-1-Methyl-3-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is specifically engineered for use in modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, which is fundamental to constructing complex molecules. It is a critical building block for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing biaryl structures.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable boronic ester reagent for palladium-catalyzed carbon-carbon bond formation, enabling the construction of complex organic frameworks.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors, where precise molecular architecture is required.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Acts as a versatile linker or component in the design of bifunctional molecules for targeted protein degradation.
• Academic & Industrial R&D: A valuable reagent for method development and exploratory synthesis in organic chemistry laboratories.

Basic Information

Product Name	1-Methoxy-1-Methyl-3-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea
CAS No.	874297-84-4
Molecular Formula	C15H23BN2O4
Molecular Weight	306.17 g/mol
Synonyms	1-Methoxy-1-methyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 4-(1-Methoxy-1-methylureido)phenylboronic acid pinacol ester; 1-Methoxy-1-methyl-3-[4-(pinacolatoboryl)phenyl]urea; Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-methoxy-N'-methyl-; [4-(1-Methoxy-1-methylureido)phenyl]boronic acid pinacol ester; CAS 874297-84-4
EINECS	Contact for details

Quality Control

Our 1-Methoxy-1-Methyl-3-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.