Description

n-Cyclopropyl 3-Borono-4-Fluorobenzamide is a high-purity boronic acid derivative and a key synthetic intermediate in modern organic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a cyclopropylamide moiety, enabling the construction of complex, pharmaceutically relevant scaffolds. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new small molecule drugs.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronic acid functionality makes it a versatile reagent for forming carbon-carbon bonds, a fundamental step in constructing complex organic molecules.
• Agrochemical Research: Used in the development and synthesis of novel herbicides, fungicides, and insecticides that require specific fluorinated and cyclopropyl-containing structures.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of advanced polymers and organic electronic materials.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	n-Cyclopropyl 3-Borono-4-Fluorobenzamide
CAS No.	874289-54-0
Molecular Formula	C10H11BFNO3
Molecular Weight	223.01 g/mol
Synonyms	3-Borono-4-fluoro-N-cyclopropylbenzamide; 4-Fluoro-3-borono-N-cyclopropylbenzamide; N-Cyclopropyl-3-borono-4-fluorobenzamide; 874289-54-0; B-(5-(Cyclopropylcarbamoyl)-2-fluorophenyl)boronic acid; 3-Carbamoyl-4-fluorophenylboronic acid, N-cyclopropyl-; Benzamide, N-cyclopropyl-3-borono-4-fluoro-
EINECS	Contact for details

Quality Control

Our n-Cyclopropyl 3-Borono-4-Fluorobenzamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	95.0% - 105.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.