Description

2-(7-Azabenzotriazole-1-Yl)-1,1,3,3-Tetramethyluronium Tetrafluoroborate is a highly effective peptide coupling reagent, commonly known as TATU. This compound is critical for facilitating efficient amide bond formation in solid-phase and solution-phase peptide synthesis, offering advantages in reduced racemization and high coupling yields. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries developing novel peptide-based therapeutics and active ingredients.

Application

• Peptide Synthesis: Primary reagent for amide bond coupling in the synthesis of complex peptides and proteins.
• Pharmaceutical Research: Used in the development and scale-up of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation: Facilitates the conjugation of peptides to other molecules, such as polymers, dyes, or drug delivery carriers.
• Combinatorial Chemistry: Employed in high-throughput synthesis for generating diverse peptide libraries for screening.
• Agrochemical Development: Applied in the synthesis of peptide-mimetic agrochemicals and bioactive compounds.
• Academic & Industrial R&D: A standard tool in laboratories for fundamental research in organic and medicinal chemistry.

Basic Information

Product Name	2-(7-Azabenzotriazole-1-Yl)-1,1,3,3-Tetramethyluronium Tetrafluoroborate
CAS No.	873798-09-5
Molecular Formula	C10H16BF4N7O
Molecular Weight	321.09 g/mol
Synonyms	TATU; 2-(7-Aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; 1-(1H-1,2,3-Triazolo[4,5-b]pyridin-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; 1-(1H-1,2,3-Triazolo[4,5-b]pyridin-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; Uronium, 2-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyl-, tetrafluoroborate(1-); TATU Coupling Reagent; Azabenzotriazole Tetramethyl Uronium Tetrafluoroborate
EINECS	Contact for details

Quality Control

Our 2-(7-Azabenzotriazole-1-Yl)-1,1,3,3-Tetramethyluronium Tetrafluoroborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with detailed specifications including assay, impurity profile, and moisture content, supporting compliance with research and cGMP guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and efficacy. For long-term storage, consider desiccants or a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in polar aprotic solvents (DMF, DMSO, Acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.