Description

L-Phenylalanine, 3,4,5-Trichloro- is a halogenated derivative of the essential amino acid L-phenylalanine, serving as a sophisticated chiral building block for advanced organic synthesis. This compound is valued for its role in introducing a sterically hindered, electron-deficient phenylalanine core into target molecules, enabling the development of novel bioactive compounds. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in protease inhibitor and peptide mimetic programs.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides, where the trichlorophenyl moiety can contribute to unique biological activity and stability.
• Peptide Chemistry: Incorporation into custom peptides to study structure-activity relationships (SAR), modulate peptide stability, or confer specific binding properties.
• Material Science: Potential monomer or precursor for specialized polymers and liquid crystals, leveraging its rigid, halogenated aromatic structure.
• Chemical Biology Probes: Serves as a building block for labeled amino acids or activity-based probes used in biochemical and cellular studies.
• Asymmetric Synthesis Catalyst Ligand: Can be utilized to derive novel chiral ligands or organocatalysts for enantioselective transformations.

Basic Information

Product Name	L-Phenylalanine, 3,4,5-Trichloro-
CAS No.	873429-67-5
Molecular Formula	C9H8Cl3NO2
Molecular Weight	268.52 g/mol
Synonyms	(2S)-2-Amino-3-(3,4,5-trichlorophenyl)propanoic acid; 3,4,5-Trichloro-L-phenylalanine; L-3,4,5-Trichlorophenylalanine; (S)-2-Amino-3-(3,4,5-trichlorophenyl)propionic acid; 3,4,5-Trichloro-DL-phenylalanine (related); Tcp-Phe-OH; Fmoc-3,4,5-Trichloro-L-phenylalanine (derivative)
EINECS	Contact for details

Quality Control

Our L-Phenylalanine, 3,4,5-Trichloro- is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity (HPLC), chemical purity (HPLC), and identity confirmation (IR, MS). A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.