Description

3-Chloro-1-(3,5-Difluorophenyl)-1-Propanone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both chloro and difluoro substituents, makes it a versatile and valuable precursor for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries. It serves as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the difluorophenyl moiety.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and advanced organic materials with unique properties.
• Ligand and Catalyst Development: Employed in the creation of complex ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: An important substrate for investigating new fluorination reactions and the effects of fluorine atoms on molecular reactivity and stability.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	3-Chloro-1-(3,5-Difluorophenyl)-1-Propanone
CAS No.	872850-57-2
Molecular Formula	C9H7ClF2O
Molecular Weight	204.60 g/mol
Synonyms	3-Chloro-1-(3,5-difluorophenyl)propan-1-one; 1-Propanone, 3-chloro-1-(3,5-difluorophenyl)-; 3,5-Difluorophenyl 3-chloropropyl ketone; 3-Chloro-1-(3,5-difluorophenyl)propanone; (3,5-Difluorophenyl) 3-chloropropyl ketone; 3-Chloro-3',5'-difluoropropiophenone
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-1-(3,5-Difluorophenyl)-1-Propanone is produced and tested under strict quality management protocols to ensure high purity and consistency. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all test results are provided with each shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.