Description

Pentanoic Acid, 4,4-Dimethyl-3-[[(Phenylmethoxy)Carbonyl]Amino]-, (3R)- is a high-purity, chiral organic building block of significant interest in advanced synthetic chemistry. Its value lies in its defined stereochemistry and functional groups, which make it a critical intermediate for constructing complex molecules with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates, particularly in medicinal chemistry programs.
• Agrochemical Research: Used in the development of novel, stereospecific pesticides and herbicides where the (3R)- configuration is crucial for bioactivity.
• Peptidomimetics & Protease Inhibitors: The structural motif is valuable for designing peptide analogs and enzyme inhibitors for therapeutic applications.
• Asymmetric Catalysis Ligand Precursor: Can be utilized to synthesize novel chiral ligands for asymmetric hydrogenation and other catalytic transformations.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis and for exploring new chemical spaces in discovery chemistry.
• Custom Synthesis Building Block: Employed by fine chemical manufacturers for the contract synthesis of specialized, high-value compounds for clients.

Basic Information

Product Name	Pentanoic Acid, 4,4-Dimethyl-3-[[(Phenylmethoxy)Carbonyl]Amino]-, (3R)-
CAS No.	872423-95-5
Molecular Formula	C15H21NO4
Molecular Weight	279.33 g/mol
Synonyms	(3R)-3-[[(Benzyloxy)carbonyl]amino]-4,4-dimethylpentanoic acid; (R)-3-((((Benzyloxy)carbonyl)amino)-4,4-dimethylpentanoic acid; 4,4-Dimethyl-3-[[(phenylmethoxy)carbonyl]amino]pentanoic acid, (3R)-; Z-Dapa-OH; N-Cbz-D-4,4-dimethylnorvaline; N-Carbobenzoxy-D-4,4-dimethylnorvaline; (R)-3-((((Benzyloxy)carbonyl)amino)-4,4-dimethylvaleric acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for downstream synthetic applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, enantiomeric excess, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.