Description

1-Methoxy-3-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6,7,8-Tetrahydroisoquinoline is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group, which is critical for modern cross-coupling reactions like the Suzuki-Miyaura reaction. Its core value lies in enabling the efficient and precise construction of complex heterocyclic scaffolds essential for drug discovery and development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to synthesize novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those containing complex tetrahydroisoquinoline cores.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to attach diverse aryl and heteroaryl groups under mild conditions.
• Agrochemical Research: Used in the development of new active ingredients for crop protection with potentially improved efficacy.
• Material Science: Serves as a precursor for creating organic electronic materials and functional polymers.
• Chemical Biology Probes: Facilitates the creation of labeled compounds for studying biological pathways and target engagement.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Methoxy-3-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6,7,8-Tetrahydroisoquinoline
CAS No.	872175-74-1
Molecular Formula	C₁₇H₂₆BNO₃
Molecular Weight	303.21 g/mol
Synonyms	1-Methoxy-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydroisoquinoline; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methoxy-3-methyl-5,6,7,8-tetrahydroisoquinoline; 1-Methoxy-3-methyl-5,6,7,8-tetrahydroisoquinoline-4-boronic acid pinacol ester; 872175-74-1; Tetrahydroisoquinoline boronic ester derivative
EINECS	Contact for details

Quality Control

Our 1-Methoxy-3-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6,7,8-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.