Description

1-(3-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethan-1-One CAS NO 871353-32-1 is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring both bromo and fluoro substituents on the phenyl ring and a trifluoroacetyl group, makes it a versatile and valuable precursor for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated organic compounds for advanced materials, such as liquid crystals, polymers, and electronic chemicals.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	1-(3-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethan-1-One
CAS No.	871353-32-1
Molecular Formula	C8H3BrF4O
Molecular Weight	270.99 g/mol
Synonyms	3'-Bromo-2'-fluoro-α,α,α-trifluoroacetophenone; 2-Fluoro-3-bromo-α,α,α-trifluoroacetophenone; 1-(3-Bromo-2-fluorophenyl)-2,2,2-trifluoroethanone; 3-Bromo-2-fluorophenyl trifluoromethyl ketone; (3-Bromo-2-fluorophenyl)(trifluoromethyl)methanone; α,α,α-Trifluoro-3-bromo-2-fluoroacetophenone; TFABF (common abbreviation)
EINECS	Contact for details

Quality Control

Our production of 1-(3-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethan-1-One adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming specifications for assay and impurity profiles. Our commitment to reliable supply and traceable quality supports critical R&D and scale-up activities for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.