Description

(1S)-1,7,7-Trimethylbicyclo[2.2.1]hept-2-en-2-ylboronic acid is a high-purity, chiral boronic acid derivative characterized by its rigid, camphor-like bicyclic structure. This compound is a critical building block in modern organic synthesis, particularly valued for its role in stereoselective carbon-carbon bond-forming reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of C-C bonds, enabling the synthesis of complex, chiral biaryl and olefinic structures.
• Pharmaceutical Intermediate Synthesis: Serves as a crucial precursor in the multi-step synthesis of chiral drug candidates, especially in medicinal chemistry for oncology and CNS diseases.
• Asymmetric Synthesis & Catalysis: Used to introduce chiral, terpene-based frameworks into target molecules, leveraging its inherent stereochemistry from the (1S)-enantiomer.
• Ligand and Catalyst Development: Employed in the preparation of novel chiral ligands for transition metal catalysis.
• Material Science Research: A building block for creating organic molecules with specific spatial configurations for advanced polymeric or electronic materials.
• Agrochemical Synthesis: Used in the research and development of enantiomerically pure active ingredients for crop protection.

Basic Information

Product Name	(1S)-1,7,7-Trimethylbicyclo[2.2.1]hept-2-en-2-ylboronic Acid
CAS No.	871333-99-2
Molecular Formula	C10H17BO2
Molecular Weight	180.05 g/mol
Synonyms	(1S)-(-)-2-Borneneboronic Acid; (1S)-2-Bornene-2-boronic Acid; (1S)-1,7,7-Trimethylbicyclo[2.2.1]hept-2-ene-2-boronic Acid; (-)-2-Borneneboronic Acid; L-(-)-2-Borneneboronic Acid; (1S)-Camphor Boronic Acid Derivative; B-[(1S)-1,7,7-Trimethylbicyclo[2.2.1]hept-2-en-2-yl]boronic Acid
EINECS	Contact for details

Quality Control

Our (1S)-1,7,7-Trimethylbicyclo[2.2.1]hept-2-en-2-ylboronic acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP standards where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will compromise quality and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.