Description

3-Nitro-5-(Piperidin-1-Ylcarbonyl)Benzeneboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical synthetic intermediate. Its core value proposition lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a piperidine-carbonyl moiety that can impart desirable pharmacological properties. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures in drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Suzuki-Miyaura Cross-Coupling Reagent: Utilized in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds, enabling the efficient construction of biaryl and heterobiaryl structures common in modern medicinal chemistry.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides, where the boronic acid and amide functionalities can contribute to target binding and metabolic stability.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, such as charge-transport layers or emissive materials in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Synthesis: Used to create molecular probes and inhibitors for studying enzyme function and biological pathways, leveraging its potential for protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific, high-purity boronic acid derivatives.

Basic Information

Product Name	3-Nitro-5-(Piperidin-1-Ylcarbonyl)Benzeneboronic Acid
CAS No.	871332-78-4
Molecular Formula	C13H17BN2O5
Molecular Weight	292.10 g/mol
Synonyms	[3-Nitro-5-(piperidine-1-carbonyl)phenyl]boronic acid; (3-Nitro-5-(piperidine-1-carbonyl)phenyl)boronic acid; 3-Nitro-5-(1-piperidinecarbonyl)benzeneboronic acid; Boronic acid, B-[3-nitro-5-(1-piperidinylcarbonyl)phenyl]-; 5-(Piperidine-1-carbonyl)-3-nitrobenzeneboronic acid; 871332-78-4 (CAS); 3-Nitro-5-piperidin-1-ylcarbonylbenzeneboronic Acid
EINECS	Contact for details

Quality Control

Our 3-Nitro-5-(Piperidin-1-Ylcarbonyl)Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.